Postdoctoral Fellow

We are a global and independent mid-sized pharmaceutical group governed by a Foundation. Our unique model makes us proud and, more importantly, enables us to fully serve our mission: "committed to therapeutic progress for the benefit of patients."

As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard-to-treat cancers and dedicating more than 70% of our R&D budget to this goal.

Who are we? 20,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

www.servier.com

About our R&D Institute in Paris Saclay

At the heart of one of the world's top eight innovation clusters, the Servier R&D Institute at Paris-Saclay is where visionary science meets a powerful global ecosystem. By uniting our Group's innovation potential with this prestigious center of excellence, we are not only accelerating the future of therapeutic discovery but also championing the global influence of French research.

Are you a fast-learning scientist passionate about optimizing clinical drug trials through the investigation of endogenous biomarkers ? We are seeking a Scientist to join our R&D organization. In this role, you will develop robust protocols to extract liver-derived extracellular vesicles (EVs) from culture media and human plasma and apply MultiOMICS (Proteomics and Transcriptomics) to monitor CYP450 and drug transporter induction/inhibition. Your work will reduce reliance on dedicated clinical DDI studies and feed into our global DDI monitoring strategy throughout clinical development.

Responsibilities

• Design and conduct experiments with primary human hepatocytes, relevant cell lines, and human samples to set up, test, and optimize liver-derived EV isolation/enrichment protocols
• Evaluate the reliability of EV-based readouts to assess xenobiotic impacts on ADME protein expression (CYP450 and drug transporters induction/inhibition)
• Optimize sample preparation to maximize data yield from minimal plasma volumes
• Perform quantitative studies of global protein and gene expression in extracted EVs and monitor induction effects
• Work transversally with scientists across R&D to execute experiments and generate/analyze proteomics and transcriptomics datasets
• Communicate results internally (presentations/posters) and externally (peer-reviewed journals, posters, conferences), where applicable