Scientist

ABOUT eGENESIS

eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.    At eGenesis, our core values—innovation, collaboration, compassion, resilience, and passion—are at the center of how we work. We engineer hope and bring passion to everything we do. We collaborate and learn from one another, combining diverse expertise to tackle complex challenges. We innovate boldly, pushing boundaries and science to new heights. where no pig organ has gone before. With resilience, we navigate challenges and celebrate progress together. And in all we do, we lead with compassion—for our patients, our people, and our pigs.

POSITION SUMMARY

We are seeking a highly skilled and motivated Scientist II with expertise in single cell and spatial genomics data analysis. The ideal candidate will play a key role in unraveling the cellular and spatial architecture of engineered organs and immune interactions in our translational research programs. This is a unique opportunity to drive high-impact research at the intersection of genomics, immunology, and synthetic biology.

PRIMARY RESPONSIBILITIES

• Identify and frame open biological questions across our programs, define the analytical strategy to address them, and set your own priorities with minimal day-to-day direction.
• Lead the design, analysis, and interpretation of single cell RNA-seq and spatial transcriptomics experiments.
• Integrate multimodal datasets, including spatial transcriptomics, scRNA-seq, proteomics, metabolomics, pathology and clinical metadata, to uncover insights into tissue remodeling and immune responses.
• Collaborate with cross-functional teams including wet lab scientists, immunologists, bioinformaticians, clinicians and translational scientists.
• Develop scalable pipelines for high-dimensional single cell and spatial datasets, and build new analytical approaches where existing tools fall short (e.g., cross-species cell mapping, sparse or incomplete reference annotations).
• Perform spatially resolved analyses of cell states, tissue architecture, cell-cell interactions, and molecular programs associated with graft injury, inflammation, remodeling, and repair.
• Translate biological and translational questions into computational analyses and testable hypotheses, with interpretation grounded in immunological mechanisms and xenotransplant biology.