Postdoc

A full-time (100%) postdoctoral position is available in the lab of Dr. Srustidhar Das, at the Department of Clinical Research and at the Research Unit of  Inflammation Research, Department of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark. 

The position is limited to two years, with the possibility of extension subject to funding.

Research tasks

The position comprises research, teaching, professional development and supervision within intestinal tissue regeneration, epithelial biology, mucosal immunology and inflammatory bowel disease (IBD). The postdoc will join a translational research programme that investigates how inflammation reshapes the intestinal epithelium and its surrounding tissue niche, and how these changes can be targeted to promote safe and durable mucosal healing.

The successful candidate will combine patient-derived organoid and co-culture models with molecular biology, functional assays, and computational analysis of single-cell and spatial datasets. The position is particularly suited to a researcher who can connect experimental biology with bioinformatics and clinically relevant questions.

Research environment

The postdoc will be embedded in a dynamic and highly collaborative research environment spanning the Department of Clinical Research and the Department of Molecular Medicine at SDU. The project benefits from close interaction among basic scientists, clinicians, bioinformaticians and translational researchers, with strong links to Odense University Hospital and access to patient-derived material, advanced disease models and state-of-the-art molecular technologies.

The environment provides excellent opportunities to develop an independent research profile, contribute to clinically relevant discoveries in IBD and tissue regeneration, and build collaborations across experimental, computational and clinical disciplines.

Research project

The project investigates how inflammatory history establishes persistent epithelial and niche memory, shapes epithelial plasticity and influences intestinal regeneration in IBD. Using patient-derived biopsies, intestinal organoids, fibroblasts and immune-cell co-cultures, we will determine how epithelial memory and injury-induced cell-state transitions influence regenerative capacity and distinguish effective from impaired mucosal healing.