General Manager
US$265,000 – US$340,000 / yr base salary
Posted 8 Sep 2026
Advertised as “General Manager, Commercial Manufacturing Facility”
BranchFactor Summary
The original posting with the fluff stripped out
- Expected experience
- 15+ yrs
- Management level
- People management
- Employment
- On-Site
- Contract
- Full-time
| Base salary | US$265,000 – US$340,000 / yr |
|---|
Field of studyBusiness, Engineering, Life Sciences, Operations (or related)
Study levelBachelor's
Study levelMaster's
More than one million people in the United States today are fighting blood cancer. While a traditional allogeneic stem cell transplant has been the best hope for many, the transplant itself can prove fatal or lead to serious conditions, such as graft vs. host disease. Orca Bio is a commercial-stage biotechnology company redefining the transplant process by developing next-generation cell therapies with the goal of providing significantly better survival rates with dramatically fewer risks. With our purified, high-precision cell therapies we hope to not only replace patients' blood and immune systems with healthy ones, but also restore their lives. We have built a state-of-the-art, 100,000-square-foot manufacturing facility in Sacramento, CA (7910 Metro Air Pkwy) to ensure the consistent and reliable delivery of our high-precision cell therapy products. This site is essential to advancing our clinical pipeline and supporting future commercial availability of our life-saving therapies.
Summary of Position: The General Manager/Site Head, Commercial Manufacturing will have overall leadership responsibility for our 200+ employee, 24/7 Sacramento manufacturing site, which has undergone significant recent expansion and continues to scale. This leader will serve as the senior site executive accountable for operational performance, manufacturing execution, people, financial performance, quality and compliance, and long-term growth.
Reporting to the Chief Quality Officer/EVP Manufacturing, the General Manager will work closely with Orca Bio’s executive leadership team to strengthen the site’s operating model, culture and capabilities while driving reliable execution, operational efficiency and continuous improvement. This is a highly visible role for a strategic business leader and hands-on operator who brings a strong sense of urgency and stays close to day-to-day operations.
Location: candidate must live and work full-time in Sacramento; relocation support will be provided as needed.
Responsibilities
Site Leadership & General Management
- Serve as the senior leader and overall business operator for the Sacramento commercial manufacturing site.
- Establish and build upon site priorities, governance, operating rhythms and performance objectives aligned with Orca Bio’s business goals.
- Lead the site leadership team and create clear accountability, fast decision-making and strong cross-functional execution.
- Build the organization, systems and capabilities required to support continued commercial growth.
- Provide executive leadership with clear visibility into site performance, risks, opportunities and resource needs. Manufacturing & Operational Performance- Lead commercial GMP manufacturing operations and ensure reliable delivery of patient-critical products.