Vice President, Clinical Operations

The Vice President of Clinical Operations will provide leadership for a clinical operations function and will be accountable for the operational strategy, execution, quality, and scalability of clinical programs supporting Janux’s innovative therapies across autoimmune indications. This executive will translate clinical development and corporate priorities into integrated operational plans, build the capabilities and organization required to support portfolio growth, and ensure delivery of clinical milestones from first-in-human development through late-stage execution. The Vice President will serve as a strategic partner to executive leadership and governance bodies, lead and develop a high-performing Clinical Operations organization, and maintain rigorous sponsor oversight of CROs, vendors, sites, timelines, budgets, quality, and risk.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Own the global Clinical Operations vision, functional strategy, and operating model, ensuring clinical execution is aligned with company objectives, portfolio priorities, and evolving development plans.
• Provide executive oversight of clinical programs from IND-enabling and first-in-human studies through later-stage development, ensuring integrated planning, disciplined execution, and readiness for future indications, geographies, and registrational pathways.
• Partner with Clinical Development, Clinical Science, Regulatory Affairs, Biometrics, Translational Sciences, Safety, CMC, Program Management, Finance, Legal, and Quality to shape development strategy and convert program objectives into executable clinical plans.
• Serve as the senior Clinical Operations representative to Executive Leadership and governance committees, providing clear recommendations on portfolio priorities, operational feasibility, risk, investment, resource allocation, timelines, and trade-offs.
• Establish portfolio-level governance, performance metrics, dashboards, and escalation mechanisms that enable proactive decision-making and consistent accountability across programs and studies.
• Lead long-range resource planning, organizational design, succession planning, and capability building for Clinical Operations; recruit, mentor, and retain leaders and teams capable of supporting a growing global portfolio.
• Create a high-performance, patient-focused culture grounded in accountability, collaboration, adaptability, operational excellence, and continuous improvement.
• Oversee clinical program budgets, forecasts, headcount plans, vendor commitments, and scenario planning; partner with Finance and executive leadership to balance speed, quality, risk, and capital efficiency.
• Define and maintain scalable clinical operations infrastructure, policies, SOPs, work instructions, systems, and standards that support inspection readiness, data integrity, and compliant global execution.
• Ensure robust sponsor oversight of CROs, central laboratories, clinical technology providers, specialty vendors, and other strategic partners, including governance, performance management, issue escalation, and relationship strategy.