Business Systems Manager
US$140,000 – US$180,000 / yr base salary
Posted 14 Oct 2026
Advertised as “Manager / Senior Manager, Business Systems”
BranchFactor Summary
The original posting with the fluff stripped out
- Expected experience
- 5–8 yrs
- Management level
- People management
- Employment
- On-Site
- Contract
- Full-time
| Base salary | US$140,000 – US$180,000 / yr |
|---|
Field of studyBusiness, Computer Science, Information Systems (or related)
Study levelBachelor's
More than one million people in the United States today are fighting blood cancer. While a traditional allogeneic stem cell transplant has been the best hope for many, the transplant itself can prove fatal or lead to serious conditions, such as graft vs. host disease. Orca Bio is a commercial-stage biotechnology company redefining the transplant process by developing next-generation cell therapies with the goal of providing significantly better survival rates with dramatically fewer risks. With our purified, high-precision cell therapies we hope to not only replace patients' blood and immune systems with healthy ones, but also restore their lives.
Orca Bio is seeking a hands-on Manager/Senior Manager, Business Systems to own the day-to-day administration, implementation, and roadmap of our business systems portfolio, with a strong focus on AI applications and supporting OrcaLink – Orca Bio’s Salesforce-based Chain of Custody / Chain of Identity (COC/COI) platform. Reporting to the Head of Business Systems and Architecture, this person will help manage our contracted software development teams, partner closely with business stakeholders across the company, and ensure our regulated and non-regulated systems are secure, compliant, scalable, and increasingly powered by AI and automation.
Essential Duties & Key Responsibilities
- Manage the full lifecycle of business systems requests – intake, requirements, configuration/build, testing, deployment, and post-launch support across Orca Bio’s platforms.
- Evaluate, implement, and integrate new business applications (CRM, ERP, QMS, MES, CTMS, HRIS, and similar) as Orca Bio’s commercial and enterprise footprint grows.
- Partner cross-functionally with business stakeholders and SMEs to translate business needs into scalable systems solutions.
- Support OrcaLink (our Salesforce-based COC/COI platform) in partnership with the OrcaLink platform owner and Salesforce administrators, contributing to configuration, release planning, and roadmap priorities as needed.
- Lead and complete IT assessments for OrcaLink in partnership with the internal Security team – evaluating site infrastructure, access controls, and data-handling practices, and tracking remediation to enable secure onboarding and ongoing connectivity.
- Identify, scope, and drive adoption of AI applications and automation across the business, prioritizing use cases that improve operations and reduce manual effort.
- Serve as the primary bridge between business stakeholders and the development team on AI and platform initiatives.
- Lead, mentor, and grow a small team of business systems analysts/administrators supporting commercial and enterprise systems.
- Support Computer System Validation (CSV) activities for GxP-regulated systems, including validation protocols and change control (QCCR), partnering closely with Quality and Validation teams.