Clinical Trial Manager

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.

 Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.

Description of Role

Centessa is seeking a (contract-to-hire) Senior Clinical Trial Manager (Sr. CTM) to lead the execution of global clinical studies from startup through closeout and clinical study report. This role is a temporary position with the potential to convert to a permanent role, accountable for study delivery, including operational strategy, timelines, budget, quality, vendor oversight, risk management, and inspection readiness. This individual in this role will lead cross-functional teams and manage CROs and external vendors to ensure studies are conducted efficiently, compliantly, and in alignment with program objectives. 

Key Responsibilities

• Lead the planning, execution, and oversight of global clinical trials from startup through closeout. 
• Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution. 
• Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.  
• Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.  
• Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.  
• Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.  
• Identify operational risks and issues, implement mitigation strategies, and escalate as appropriate. 
• Lead study team meetings and provide regular updates to stakeholders and senior management.  
• Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle. 
• Support regulatory submissions, audits, inspections, and Health Authority interactions.  
• Contribute to process improvements and mentor junior clinical operations team members as needed. 
• Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.