Vice President, Early Pipeline Delivery

Overview 

Alnylam is seeking an experienced executive leader to stand up and lead a new, dedicated team within the Pipeline Delivery organization focused on accelerating speed-to-Proof-of-Concept (PoC) across the company's rapidly growing early development portfolio. Reporting to the SVP, Pipeline Delivery, the Vice President of Early Pipeline Delivery will design an early pipeline operating model, establish ways-of-working, and lead cross-functional capability building, while driving execution on priority studies.

Alnylam’s early stage portfolio is expanding quickly with plans to double in size by 2030, and Phase 1/2 programs already represent >60% of the 2027 pipeline. This role is central to Alnylam's ambition of achieving industry-leading, top-quartile (top-decile for Tier 1 programs) speed-to-PoC performance.

Key Responsibilities

Team Leadership & Build

• Lead the onboarding and build-out of the new Early Pipeline Delivery team and expand scope to additional studies as the team scales and development candidates (DCs) are endorsed to move into the clinic.
• Recruit, develop, and manage a team of study leads who carry operational accountability for early stage studies.
• Serve as the senior point of accountability for early phase studies, providing hands-on leadership on priority programs while building organizational depth.

Operating Model & Capability Building

• Own the design and evolution of the operating model, scaling toward a fully dedicated early pipeline study management function.
• Develop and institutionalize a playbook covering healthy-volunteer and patient models, country strategy, protocol operationalization, and vendor selection, ensuring learnings transfer across programs rather than being re-solved study by study.
• Integrate adaptive execution practices across Pipeline Delivery and partnering functions, and apply AI-enabled tools for feasibility and enrollment forecasting to accelerate PoC timelines.
• Establish standardized ways-of-working and consistent performance oversight across early development studies, replacing today's reactive, program-by-program approach with proactive risk anticipation.

Cross-Functional Influence & Portfolio Impact

• Partner closely with Global Trial Strategy & Operations, Research & Early Develpoment, and Technical Operations & Quality to manage the critical path from development candidate nomination through CTA and into PoC.
• Provide input on portfolio prioritization and resourcing, ensuring Early Pipeline Delivery leadership maintains sufficient influence and connectivity across both dedicated and transitioning studies.
• Support delivery of complex, novel study types — including first-in-human, healthy-volunteer, and novel-country studies (e.g., Australia, China) — and emerging therapeutic areas such as ophthalmology and neuromuscular disease.
• Represent Early Pipeline Delivery to senior R&D and Pipeline Delivery leadership, reporting on progress, risks, and resourcing needs as the function scales.

Qualifications

• MSc, MBA, PhD or equivalent in relevant discipline strongly preferred
• 20+ years industry experience focused on Clinical Operations with significant experience leading early-stage study management within a biopharmaceutical company, including direct accountability for Phase 1/2 program delivery.
• Track record of building or scaling a team or operating function, ideally including standing up new organizational capabilities in a growth environment.
• Experience with first-in-human and healthy-volunteer study designs; exposure to novel or emerging geographies is a plus.
• Demonstrated success driving cross-functional alignment
• Strong operational and analytical rigor, with comfort using data and benchmarking to diagnose bottlenecks and drive continuous improvement.
• Builder's mindset — energized by ambiguity and the opportunity to shape a new function rather than inherit an established one.
• Executive presence and communication skills sufficient to influence senior R&D leadership and partner functions without direct authority.
• Familiarity with applying AI-enabled tools to clinical feasibility and enrollment forecasting.

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

U.S. Pay Range$301,800—$408,200 USD