Manufacturing Supervisor

Overview

The Supervisor, Manufacturing is an integral part of the Norton Internal Manufacturing team. This role will initially be involved in the start-up of Norton’s new commercial Drug Substance manufacturing train, including support for equipment commissioning & qualification, generation of GMP documentation, and successful execution of Drug Substance engineering and PPQ batches all the way through commercial production and launch. The Supervisor is responsible for hiring and managing manufacturing technicians to support the start-up activities and successful execution of manufacturing campaigns. 

This position is a first-shift on-site role in Norton, MA  that will report to the Manufacturing Sr. Manager. The role is executed primarily on the floor inside the manufacturing suite.

Key Responsibilities

• Day-to-Day People Management
  • Lead, coach, and develop a team of technicians to ensure safe, compliant, and efficient operations.
  • Recruit, hire, onboard, and train new team members.
  • Foster a positive, safety-focused culture aligned with Alnylam's values and leadership principles.
  • Set clear goals and expectations, provide regular feedback, and support employee development.
  • Conduct routine 1:1s, performance reviews, and training assessments to drive engagement and performance.
  • Provide floor leadership, balancing operational priorities, project work, and team development.
  • Address employee relations and performance issues in partnership with Human Resources as needed.
  • Build a high-performing team focused on quality, continuous improvement, and operational excellence.
• Commercial Train Start-Up
  • Support for new equipment commissioning & qualification testing, including attending Factory Acceptance Tests (FAT’s), reviewing/approving protocols as the end user subject matter expert, and assisting on-the-floor protocol execution
  • Creation and approval of GMP documentation, including SOP’s and batch records
  • Assisting with planning and directing an efficient layout of equipment and flow of materials
  • Assisting with design and implementation of electronic logbooks, batch records, and workflows within a new Manufacturing Execution System
• Independent Resolution of Complex Problems
  • Monitor process and troubleshoot upset conditions that may arise (equipment issues, opening deviations, inability to follow SOP, etc.)
  • Thorough understanding of GMP Standards, leading by example and escalating problems through the quality and manufacturing organization as needed
  • Technical process experience assessing equipment output to ensure it meets process expectations Independently assess situations and respond with appropriate sense of urgency to issues as they occur