Clinical Pharmacology Director

ABOUT LAKEFRONT BIOTHERAPEUTICS

Lakefront Biotherapeutics is a global biotech with offices in Belgium, Chicago and San Francisco, focused on building a differentiated immunology and inflammation pipeline to address serious diseases with high unmet medical need. Our pipeline is anchored by T‑cell engager programs, led by a potential first‑in‑class clinical asset and complemented by an exciting preclinical portfolio in autoimmune disease.

Our lead asset is being developed for severe immune‑mediated diseases, while additional preclinical programs expand the long‑term potential of our R&D pipeline. At Lakefront, we focus on advancing programs with strong biological rationale, clear clinical proof of concept and large commercial opportunities.

Are you ready to transform lives and be part of a journey like no other? We are building a company where science, execution, and accountability matter. Rather than layers of hierarchy, we operate with small, empowered teams that work hands‑on across development stages to move programs forward efficiently and thoughtfully.

We are looking for people who want to contribute directly, who are motivated by solving real problems, collaborating across disciplines, and taking ownership from idea to impact. At Lakefront, every role plays a part in shaping the future of medicines that have the potential to make a meaningful difference for patients.

If you are driven to improve the lives of patients, energized by execution, and excited to help build a growing company with a strong balance sheet, we look forward to meeting you.

The Role

We are seeking a Director or Senior Director of Clinical Pharmacology to lead clinical pharmacology strategy and execution across our autoimmune pipeline. This is a key high-impact, high-visibility role that will shape how our molecules are characterized, dosed, and differentiated in the clinic. You will work at the intersection of quantitative modeling, translational medicine, regulatory strategy, and clinical development — and will have the opportunity to build out the clinical pharmacology function as the company grows.

What You'll Do

• Lead clinical pharmacology strategy and implementation across one or more programs, from first-in-human through proof-of-concept and beyond
• Develop and execute multidisciplinary clinical pharmacology plans including characterization of PK, evaluation of PK/PD and exposure-response relationships, and dose optimization strategies
• Analyze data from ongoing and completed clinical trials to identify dose- and exposure-related trends and signals in safety, efficacy, and patient subgroups to support development decisions
• Contribute to the design of clinical studies to support evidence generation and development objectives
• Integrate quantitative modeling techniques (e.g. population PK, PK/PD, PBPK, QSP) throughout development to inform dose selection, trial design, and labeling as needed