Scientist
US$155,000 – US$200,000 / yr base salary
Posted 17 Apr 2026
Advertised as “Principal/Senior Scientist, Translational Biomarkers”
BranchFactor Summary
The original posting with the fluff stripped out
- Expected experience
- 5+ yrs
- Management level
- People management
- Employment
- On-Site
| Base salary | US$155,000 – US$200,000 / yr |
|---|
Field of studyBiochemistry, Cell Biology, Molecular Biology (or related)
Study levelDoctorate
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
This Position
NewLimit is seeking a Senior/Principal Scientist with deep expertise in molecular biology and translational biomarker assay development. In this role, you will lead the discovery, development, and qualification of pharmacodynamic (PD) biomarker assays that characterize the biological activity of our mRNA-LNP medicines in preclinical and IND-enabling studies. You will serve as a technical leader within our bioanalytical function, shaping PD biomarker strategy from discovery through fit-for-purpose qualification to advance our therapeutic programs toward clinical milestones.
What you’ll do
- Discover pharmacodynamic biomarkers to support the clinical development of drugs across multiple programs
- Own the design, development, and qualification of PD biomarker assays across various platforms to support preclinical studies
- Define go/no-go criteria for biomarker advancement and contribute to the PD biomarker strategy in regulatory submissions
- Drive data analysis, interpretation, and reporting for bioanalytical studies
- Contribute to sample processing workflows including tissue harvesting, primary cell culture, and complex matrix handling
- Mentor research associates, establish SOPs, and build institutional knowledge within the bioanalytical function
Requirements
- PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years)
- 3+ years of hands-on experience in various quantitative bioanalytical assay platforms (e.g., RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS-based methods) in complex biological matrices (serum, plasma, tissue homogenates)
- Strong working knowledge of bioanalytical method qualification/validation principles for PD biomarker measurements, including familiarity with ICH M10 guidelines and fit-for-purpose frameworks
- History of delivering results for bioanalytical projects -- you've discovered a PD biomarker or built an assay and solved all the problems along the way
- Experience with primary cell culture and tissue-derived sample workflows