Supplier Management, Operations & Portfolio Management Director

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

Revolution Medicines is seeking a motivated individual with a scientific background to play a critical role as the supplier management lead for drug substance within the Pharmaceutical Development and Manufacturing (PDM) function. This position will be responsible for business and technical operations in support of PDM outsourcing activities and leading strategic initiatives to enable planning, sourcing, production, and delivery of Revolution Medicines’ drug supply, with focus on drug substance, regulatory starting material, and raw material. This role is an individual contributor with cross-functional team leadership responsibilities, reporting into the Senior Director, Head, Supplier Management, Operations & Portfolio Management, Pharmaceutical Development & Manufacturing.

• Responsible for ongoing management of RevMed’s global network of Drug Substance and raw material manufacturers.

• Drive implementation of RevMed’s CMO Lifecycle Management Program across our network of Drug Substance CMOs.  Support identification, selection, on-boarding, start-up and ongoing management of CMO’s. 

• Lead CMO management activities, including business and manufacturing support, issue resolution, and performance management.  Lead weekly cross-functional site leadership team meetings with CMO to ensure all start-up and production activities are conducted successfully on-time. 

• Understand CMO partner internal structure and processes and work with team to ensure successful production, issue resolution and communication takes place to meet RevMed’s production requirements. 

• Lead site issue management and resolution during routine production and escalate issues, when appropriate.  Drive risk management activities, including the identification of risks and creation of mitigation plans.  Support product transfer activities to the CMO.

• Establish and maintain effective relationships with key CMO stakeholders to ensure successful manufacture and issue resolution across the external manufacturing network.  Foster collaborative relationships with internal stakeholders (e.g. Clinical Operations, Development, Regulatory, Quality, Operations, Finance, etc.) to understand organizational needs.

• Create and manage contracts, requests for pricing, supply agreements, etc. Ensure activities are executed in alignment with established Supply and Quality Agreements.  Work with stakeholders and suppliers to help drive business issues to resolution.  Understand contractual / financial implications of issues and solutions and ensure appropriate outcomes are implemented.  Manage and communicate forecasts to the sites.  Support capacity planning activities.

• Manage CMO Performance.  Measure and report on the overall performance of each CMO.  Identify and drive performance improvements (COGS, cycle time, quality, etc.) to ensure efficient, reliable supply of all clinical and commercial products.

• Work collaboratively with Project Management to ensure projects from conception to implementation and close-out, as directed by management.

• Serve as Revolution Medicines’ primary business operation lead and project management interface between internal PDM functions and CRDMOs for Drug Substance by providing adequate oversight.

• Ensure projects/programs meet desired results, compliance, speed, quality, and cost.

• Support cross-functional CRDMO management activities, covering all aspects such as business needs identification, market screening, contracting, vendor qualification and set-up, compliant delivery of services, and discontinuation.

Required Skills, Experience and Education:

• B.Sc. or M.Sc. in scientific field with 15+ years of experience in pharmaceutical strategic sourcing and/or supply chain.

• Experience working with domestic and international CRDMOs.

• Experience with managing late phase and commercial projects.

• Experience managing both strategic and tactical/operational projects.

• Working knowledge of and experience in clinical manufacturing, regulatory, QA, and cGMP requirements for small molecules.

• Working knowledge of small molecule drug development and commercialization, including, but not limited to, oral solid dosage form development and manufacturing, scale-up, and validation.

• Working knowledge of pharma end-to-end supply chain, with oral solid dosage form related supply a plus.

• Strong negotiation skills.

• Solid project management, facilitation, and problem solving skills.

• Solid organizational and time management skills.

• Effective, open, and transparent communication skills (verbal and written).

• Capable of working on multiple projects/tasks and able to meet timelines.

• Self-starter with a high-level of comfort with ambiguity and complexity and the ability to multi-task while consistently delivering quality results.

• Team-oriented, progressive thinker who enjoys participating in an innovative and creative work environment.

Preferred Skills:

• Experience in implementing and/or managing inventory management system.

• Working knowledge of commercial manufacturing.

• Experience developing, negotiating, and executing clinical or commercial supply and/or quality agreements.

#LI-CT1 #LI-Onsite

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range$211,000—$264,000 USD

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
 
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
 
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