Sample Management Manager

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

**The Opportunity:
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• Provide direct, hands-on leadership to sample management staff, including daily work assignment, prioritization, and real-time problem solving.

• Lead and participate in core sample management activities, including sample receipt, storage, tracking, retrieval, and disposal.

• Ensure smooth day-to-day operation of automated storage systems, LIMS, and supporting laboratory infrastructure.

• Train, mentor, and develop staff through on-the-job coaching, feedback, and performance management.

• Develop, maintain, and enforce SOPs and best practices for all critical sample management processes.

• Identify and implement process improvements to enhance efficiency, reliability, and scalability.

• Serve as the primary point of contact for cross-functional partners, ensuring timely and accurate delivery of materials.

• Work closely with the Director of Sample Management to communicate capacity, risks, and resource needs.

• Support onboarding and ramp-up of new staff and technologies within the laboratory.

• Provide technical leadership and subject matter expertise in tissue culture, including aseptic technique, routine cell line maintenance, culture optimization, cryopreservation, thawing, and recovery.

• Lead the design and execution of fit-for-purpose cell banking strategies, including the creation, expansion, characterization, qualification, release, use, and retirement of research, master, and working cell banks.

• Plan and oversee cell bank expansion activities, including seed-train design, passage management, scale-up scheduling, resource allocation, and assessment of growth, viability, and recovery performance.

• Establish and maintain cell bank inventory controls that ensure unique identification, accurate storage locations, complete metadata, chain of custody, inventory reconciliation, capacity planning, and full lifecycle traceability.