Scientist, Analytical Development

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

• Lead day-to-day operations to provide analytical support for API process R&D and manufacturing, formulation development and drug product manufacturing, and participate in cross-functional project team meetings.

• Contribute to analytical development strategy for multiple projects.

• Demonstrate technical expertise on analytical technologies and act as a subject matter expert for Analytical Development function.

• Select appropriate analytical techniques and coach and/or manage the contract lab counter parts to perform analytical method development/validation/transfer to support development and manufacturing of API and drug product.

• Critically review data from contract partners (CDMOs and/or CTLs).

• Manage stability testing programs assigned.

• Prepare, review, and/or approve study protocols, study reports, and CMC regulatory submission document.

• Collaborate with cross functional teams including but not limited to Medicinal Chemistry, DMPK, Toxicology, QA, Pharmaceutical Development, Process R&D, Project Management and Regulatory to timely achieve project goals.

Required Experience, Skills and Education:

• Master’s degree with 10+ years or PhD with 8+ years of relevant industrial experience in analytical development.

• Extensive experience leading analytical activities independently in small molecule drug development.

• Experience managing projects at CROs/CDMOs.

• Work experience and knowledge of regulatory submission (IND, IMPD, and / or NDA).

• Effective written and verbal communication skills and interpersonal skills.

• Extensive knowledge and understanding of current ICH guidelines, GMP guidelines, and related industry practices.