Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment. Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology.

Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere.

Summary:

Calyxo is seeking an experienced Senior IT Operations Manager to own the infrastructure backbone of the company as we scale toward and through IPO. This role leads day-to-day IT operations, ensuring reliable, secure, and responsive technology services that support Calyxo’s employees and business objectives. You will own our enterprise network and endpoint infrastructure — including switching, firewall, and wireless environments — and will be the operational lead for our core security tooling stack (endpoint detection and response, security awareness training, and endpoint/cloud security).

You will also establish company-wide software license tracking, author and maintain IT policies and procedures, and own SOX testing and evidence management for IT general controls as Calyxo builds a public-company-grade control environment. As the team scales, this role will eventually take on oversight of the helpdesk/end-user support function.

This is a foundational, build-oriented role — you will inherit a growing environment and be responsible for hardening it, documenting it, and scaling it to support a ~500-employee, pre-IPO medical device company.

In This Role, You Will:

Network & Infrastructure Operations

Own the design, deployment, and ongoing administration of Calyxo’s network infrastructure, including enterprise-grade switches, firewalls, and wireless access points across HQ and manufacturing sites.

Monitor network performance, capacity, and uptime; troubleshoot and resolve complex connectivity, routing, and security issues.

Lead infrastructure and network build-out for new and expanding facilities (e.g., the Rosewood manufacturing site), including physical security and building management system integration.

Maintain server, storage, and cloud infrastructure supporting business operations, in partnership with the broader IT team.

Security Operations & Tooling

Serve as the operational owner of Calyxo’s core security tooling stack, including security awareness training and phishing simulation, endpoint detection and response (EDR), and endpoint/cloud security platforms.

Monitor security alerts and incidents, drive remediation, and continuously improve the company’s security posture.

Partner with leadership to define and enforce security policies, access controls, and incident response procedures.

Software Asset & License Management

Establish and maintain a company-wide software license tracking process, ensuring accurate visibility into license counts, utilization, renewals, and compliance.

Identify opportunities to optimize license spend and eliminate underutilized or duplicate software.

Partner with Finance and department leaders on software budgeting and vendor renewals.

IT Policies, Procedures & SOX Compliance

Develop, document, and maintain IT policies and procedures covering infrastructure, security, access management, and change control.

Own IT General Controls (ITGC) testing, evidence collection, and audit support for Sarbanes-Oxley (SOX) compliance, partnering with Internal Audit, external auditors, and Finance.

Ensure IT controls and documentation are audit-ready and support the company’s transition to public-company operating standards.

Team & Vendor Leadership

Serve as the operational leader for IT infrastructure and, as the team scales, assume oversight of the helpdesk/end-user support function.

Manage relationships with infrastructure, network, and security vendors, including contract negotiation, service-level expectations, and performance management.

Provide technical guidance, mentoring, and feedback to IT operations staff, promote knowledge sharing, and help build a collaborative, accountable team culture.

As the IT Operations function grows, support hiring and onboarding, help define roles and team operating rhythms, and be prepared to assume direct people-management responsibility.

Other duties as assigned by manager.

Who You Will Report To:

Sr. Director, Information Technology

Requirements:

Bachelor’s degree in Information Technology, Computer Science, or a related field, or equivalent practical experience.

12+ years of progressive IT infrastructure/operations experience, including 3+ years of direct people-management experience leading IT infrastructure, operations, helpdesk, or security teams.

Hands-on, specific experience configuring, administering, and troubleshooting enterprise-grade switching, firewall, and wireless network equipment (e.g., Cisco, Cisco Meraki, Palo Alto Networks, Fortinet, Juniper, Aruba, or similar) is required.

Strong understanding of networking fundamentals (routing, switching, VLANs, VPN, firewall policy, wireless design).

Direct experience administering enterprise-grade security awareness and endpoint protection platforms (e.g., KnowBe4, Proofpoint, CrowdStrike, SentinelOne, Microsoft Defender, or similar).

Experience administering enterprise endpoint, identity and access management, and cloud infrastructure environments, such as Microsoft Intune, Jamf, Microsoft Entra ID, Okta, Azure, AWS, or similar platforms.

Demonstrated experience directly managing and developing IT operations or technical support teams, including hiring, setting performance expectations, coaching, performance management, and career development.

Experience developing and maintaining IT policies and procedures.

Experience with software asset/license management processes and tools.

Excellent problem-solving, communication, and organizational skills, with the ability to prioritize and manage multiple projects simultaneously.

Strong oral, written, and interpersonal communication skills, with the ability to work effectively across functions and with executive leadership.

Work location: Pleasanton, CA (onsite).

Full-time employment.

Preferred Qualifications:

Experience managing SOX ITGC testing, evidence, and audit support; public company or pre-IPO experience strongly preferred.

Experience in a biotech, medical device, or other regulated life sciences environment is nice to have.

Experience managing or building a helpdesk/service desk function.

Relevant certifications (e.g., CCNA, Network+, CompTIA Security+, or similar) are a plus.

Experience operating in a high-growth or scaling organization.

What We Offer:

At Calyxo, you will be part of a knowledgeable, high-achieving, experienced and fun team. You will work in a diverse work environment with experienced, proven leaders and have an opportunity to shape our company culture. You will experience constant learning and dynamic challenges to help you grow and be the best version of yourself.

We also offer an attractive compensation package, which includes:

A competitive base salary of $180,000 - $195,000 and variable incentive plan
Stock options – ownership and a stake in growing a mission-driven company
Employee benefits package that includes 401(k), healthcare insurance and paid vacation

Calyxo is deeply committed to fostering an environment where diversity and inclusion are not only valued but also prioritized. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. Diverse viewpoints bring diverse capabilities, which strengthen our focus and fuel our growth.

Calyxo is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify their identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Disclaimer:

At Calyxo, we prioritize a transparent and structured interview process to ensure the best fit for both our candidates and our team. Please be aware of the following:

Structured Interview Process: Our hiring process includes multiple stages of interviews where you will have the opportunity to communicate directly with Calyxo employees. This ensures that you gain a comprehensive understanding of the role and our company culture.
Verification of Identity: We do not extend job offers without first meeting candidates, either virtually or in person. This step is crucial to maintain the integrity of our hiring process and to ensure mutual alignment.
Beware of Scams: Calyxo will never request sensitive personal information, such as your full name, address, phone number, or identification documents, via email or online forms before an official interview. Calyxo representatives will always contact you using an email format of firstname.lastname@calyxoinc.com. If you receive a request for information from any other domain, please contact us directly at info@calyxoinc.com to verify the legitimacy of the communication.

We appreciate your interest in joining Calyxo and look forward to getting to know you through our official channels.