Scientist, Protein Sciences

Company Overview:

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety.

Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. 

Become the next standout single strand!

Job Summary:

Strand is seeking a highly motivated and innovative Senior Scientist of Protein Sciences to join our Platform Enabling Technologies team. This founding role will establish and lead protein science capabilities that enable the discovery, engineering, and validation of protein payloads, binders, and reagents for Strand’s programmable RNA medicines.

Reporting to the Associate Director of Platform Enabling Technologies, the ideal candidate combines deep expertise in nanobody or antibody engineering, computational protein design, high-throughput protein purification and characterization, and enthusiasm for building new scientific functions while remaining active on the bench.

This role integrates experimental protein sciences with AI-enabled design to discover and optimize antibodies, nanobodies, and other therapeutic proteins. Working closely with our computational biology, RNA biology, delivery, and translational teams, the scientist will define protein design criteria, lead experimental validation, and connect molecular attributes, including expression, folding, secretion, stability, activity, and developability as recombinant protein and following RNA delivery.

Primary Responsibilities:

• Establish and lead the Protein Sciences function by defining the scientific priorities, managing external vendors, selecting technology and instrumentation, and building workflows for binder discovery, protein engineering, production, and characterization.