Bioinformatics Scientist

ABOUT SINGULAR GENOMICS

Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context. Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine.

We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.

Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.

Position Summary:

As a Senior Scientist on the Bioinformatics team, you will play a key role in expanding Singular Genomics' spatial biology platform and service offerings. This position sits at the intersection of computational biology, assay development, and hands-on scientific computing. You will report into the Bioinformatics functional group and, initially, be matrixed into the Panel Design team to focus on its most pressing needs. Your initial focus will be supporting the design and optimization of targeted in situ transcriptomics panels for tissue- and disease-specific applications. This includes selecting biologically informative genes for cell type identification, defining pathway-focused content that enables cell-state interpretation, and developing computational tools to automate and improve panel design. As the platform and services continue to evolve, you will contribute to the development of spatial bioinformatics workflows, analysis pipelines, and computational methods that enable customers to generate meaningful biological insight from spatial multiomics data. This is an ideal role for someone who enjoys applying computational approaches to challenging biological problems while building software that directly impacts cutting-edge products and services. This position can be remote or hybrid/on-site. If remote, travel to the headquarters in San Diego, CA will be required at least quarterly.

Responsibilities:

Primary Responsibilities:

• Support the computational design and optimization of targeted spatial transcriptomics panels for tissue- and disease-specific applications.