DMPK Scientist

We’re seeking a DMPK Scientist to join us in our mission to transform the discovery of therapeutics!

Our drug discovery and preclinical development team includes a cross-functional group of  scientists and drug developers with experience working on all common target classes and  therapeutic areas. The group is supported by more than 100 software developers and  engineers, as well as a large-scale compute infrastructure to apply our proprietary physics based drug design and optimization platform. Ten of the programs we’ve worked on have  progressed into preclinical development, with nine currently in clinical trials and one approved  by the FDA.  

Who will love this job: 

• A DMPK analysis expert, who understands ADME principles and applications throughout drug development applications throughout drug discovery and development 
• A scientist with a robust background in DMPK who has specialized in the use and application of any of the following:

o In vitro/in vivo drug metabolism or transporter approaches to identify potential ADME liabilities and aid in compound optimization

o PK/PD and PBPK modeling approaches to optimize compound selection, dose optimization, and study design (this includes experience with commonly-used PK/PD software, such as Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology, or other equivalent software)

• A proven Principal Investigator and scientific strategist who’s self-driven and results-oriented
• A highly motivated, self-driven, and results-oriented data-analyzer 
• An excellent communicator and presenter who can work both as a team player and a  project driver 
• A flexible, curious scientist who’s excited about networking and building internal  and external relationships 

What you will do: 

• Develop and drive DMPK and PK/PD strategy for drug discovery projects 
• Represent the DMPK group on internal and intercompany project teams to help turn molecular modeling design ideas into druggable novel chemical entities 
• Collaborate with internal and intercompany project team members and external CROs to  generate relevant data to enable knowledge and data integration 
• Analyze and integrate in silico ADME predictive solutions, physicochemical, ADME, and  DMPK data to impact multiparameter optimization 
• Author and/or review appropriate reports for regulatory submission of development drug  candidates and ensure the overall quality of the studies and interpretation (this entails supporting interactions with regulatory agencies)
• Collaborate with scientific development team on establishment  of predictive computational ADME/DMPK models 

What you should have: