Program Manager

Sr Staff Program Manager, MES Custom Software Development Transformation                                                            (Hybrid in South San Francisco, CA or Wilsonville, OR)

Summary

Twist Bioscience is embarking on a strategic transformation of its Manufacturing Execution System (MES) to modernize our technology platform, enable operational scalability, and support the evolving needs of our business. We are seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and hands-on execution of this business-critical initiative.  Reporting directly to the Sr Director of Technology Operations, this role will lead the delivery of the MES replatform efforts, bringing structure, Agile delivery discipline, and strong program governance to ensure successful execution. Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions.

Key Responsibilities

• Strategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap.
• MES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.
• Stakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues.
• Budget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.
• Process & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.
• Risk & Quality Management: Proactively identify technical, operational, and integration risks. Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments.

Qualifications

• Education: Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field. 
• Overall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
• Agile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles.