Site Reliability Engineer
US$160,000 – US$225,000 / yr base salary
Posted 9 Jun 2026
Advertised as “Staff Site Reliability Engineer”
BranchFactor Summary
The original posting with the fluff stripped out
- Expected experience
- 7+ yrs
- Management level
- Individual contributor
| Base salary | US$160,000 – US$225,000 / yr |
|---|
About Manifold
Manifold is the AI platform for life sciences, accelerating life-changing medicines to patients. Our products speed up workflows in areas from target identification and clinical development to market access and precision medicine in the clinic, while maintaining the governance life sciences requires. Global companies and premier research institutions use Manifold to operate faster and more effectively. Backed by leading investors including Reach Capital, TQ Ventures, Calibrate Ventures, SilverArc Capital, and Industry Ventures, Manifold serves tens of thousands of users across hundreds of organizations globally.
About the Role
Manifold is looking for a Staff Site Reliability Engineer (SRE) to work at the intersection of AI, data infrastructure, and life sciences. In this high-impact role, you will help design, build, and operate the multi-account AWS infrastructure that acts as the foundation for Manifold’s platform.
As a Staff SRE, you'll work closely with Platform engineering and Professional Services teams to ensure Manifold’s internal and customer-facing infrastructure is secure, scalable, and observable. SREs are expected to be fluent across a wide-ranging tech stack, and comfortable working in a high-pressure, multi-threaded environment. They are also expected to balance a bias towards automation with more pragmatic approaches and have an intuitive understanding of the tradeoffs involved. The infrastructure you deploy and manage will play a key role in Manifold's success and help our customers bring life-changing medicines to patients faster.
What You'll Do
- Design and maintain infrastructure as code solutions, thinking holistically about topology and component dependencies. You will have full responsibility for everything from Terraform plans to production observability.
- Automate customer infrastructure deployments, including multi-account provisioning, database setup, workflow orchestration, and application bootstrapping.
- Manage CI/CD pipelines, including build reliability, test stability, and deployment automation for Manifold services.
- Troubleshoot complex production issues across infrastructure, data, and application layers. Leverage LLM to the fullest extend to minimize toil and and manage date to date operations.
- Networking and security / compliance work required for highly regulated environments.
What You’ll Bring
- 7+ years in infrastructure, DevOps, SRE, or platform engineering roles with increasing scope and autonomy. You are a leader / doer who can establish operational standards and drive technical direction while also staying hands-on.