Research Associate
US$70,000 – US$105,000 / yr base salary
Posted 21 Sep 2026
Advertised as “Senior Research Associate”
BranchFactor Summary
The original posting with the fluff stripped out
- Expected experience
- 1–3 yrs
- Management level
- Individual contributor
- Employment
- On-Site
| Base salary | US$70,000 – US$105,000 / yr |
|---|
Field of studyBiochemistry, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology, Pharmaceutical Sciences (or related)
Study levelBachelor's or higher
About Sail:
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
The Role:
Sail Biomedicines is seeking a motivated Senior Research Associate to join our Targeted Drug Delivery team. This role will support the development of targeted lipid nanoparticle (TNP) formulations and is a unique opportunity to be an integral part of a team dedicated to creating a transformative delivery platform for precision-targeted therapeutics.
This lab-based, onsite position requires hands-on experimental work, collaborative problem-solving, and close collaboration with cross-functional teams to drive project success. The ideal candidate will have experience in nanoparticle formulation, ligand conjugation, analytical characterization, and robust record-keeping. You will work closely with scientists and cross-functional collaborators to execute experiments, generate high-quality data, and contribute to advancing Sail’s delivery platform.
Responsibilities:
LNP Formulation & Evaluation
- Synthesize, formulate, and optimize targeted nanoparticle (TNP) formulations for nucleic acid delivery.
- Prepare TNP batches to support in vitro and in vivo studies.
- Evaluate TNP performance in vitro, including transfection efficiency, potency, and stability.
- Conduct formulation screening and optimization of novel lipid and nanoparticle materials to improve delivery performance, stability, and manufacturability.
- Improve robustness and reproducibility of formulation workflows.
- Perform physicochemical and biophysical characterization of nanoparticles and conjugates using techniques such as: DLS (particle size, PDI), Zeta potential, UV-Vis and fluorescence spectroscopy, SDS-PAGE, LC/MS (as applicable)
- Assist in developing and executing assays to assess encapsulation efficiency, conjugation efficiency, stability, and potency.
Data Analysis & Collaboration
- Analyze data, maintain accurate documentation, and present findings internally.