Scientist

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform brings together programmable circular RNA technology (eRNA™), targeted nanoparticle delivery, and advanced computational approaches to design medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

Sail Biomedicines is seeking a highly motivated and scientifically rigorous Senior Scientist to join the Analytical Sciences team. This individual will lead analytical method development, optimization, qualification, and transfer activities supporting Sail’s eRNA and lipid nanoparticle programs.

The Senior Scientist will work at the interface of analytical development, process development, formulation, manufacturing, and product characterization. This individual will apply strong scientific judgment to solve complex analytical challenges, generate high-quality data, and develop phase-appropriate methods and testing strategies that support preclinical and clinical program advancement.

The successful candidate is self-motivated, curious, collaborative, and comfortable operating in a dynamic, fast-paced environment. This role requires strong technical leadership, attention to detail, and a commitment to translating analytical insights into program decisions and meaningful impact for patients.

Responsibilities

• Lead the development, optimization, qualification, and transfer of analytical methods for RNA drug substance, lipid nanoparticle drug product, process intermediates, raw materials, and in-process samples.
• Design and execute scientifically rigorous studies to characterize product quality, purity, potency, identity, concentration, and other critical quality attributes.
• Develop phase-appropriate analytical methods and define method performance criteria based on product knowledge, program stage, and intended use.
• Independently troubleshoot complex analytical and technical challenges and develop creative, data-driven solutions.
• Lead investigations of product- and process-related impurities, degradation pathways, method performance issues, and atypical analytical results.
• Collaborate cross-functionally with Process Development, Preclinical Manufacturing, MS&T, and platform teams to advance program goals.
• Evaluate and implement new analytical technologies that improve method robustness, sensitivity, throughput, scalability, or compliance.
• Author and review analytical procedures, protocols, technical reports, and study summaries.
• Maintain thorough and accurate documentation in electronic laboratory notebooks and relevant data management systems.
• Analyze and interpret complex datasets and present findings clearly in oral and written formats to internal and external stakeholders to enable alignment and decision-making.