Strategic Operations Manager

Reporting directly to the COO, the Manager, Strategic Operations serves as a force multiplier for the leadership team, ensuring priorities translate into disciplined execution. This role is responsible for maintaining work management platforms, operational playbooks, financial and IT systems. The Manager, Strategic Operations will help build and sustain the operational backbone of the company. You will also work closely with the COO on internal communications, board and investor materials and core organizational workflows. This role requires exceptional attention to detail, strong judgment, and a commitment to high professional standards.

About Epistemix

The most consequential decisions in public health, life sciences, insurance, and enterprise strategy share a common problem: they involve human behavior, network effects, and downstream effects that cannot be safely tested before action is taken. Traditional analytical techniques built on historical data were not built for this. Epistemix was.

We build simulation and data-driven modeling tools that let leaders visualize how strategies will unfold across populations and systems before they commit resources. By clarifying which variables drive outcomes, where leverage exists, and how they interact, we help organizations move from uncertainty to conviction. Getting these decisions right means faster interventions, better-allocated resources, and measurable improvements in human and economic outcomes. We exist to make that possible.

Our platform gives organizations access to realistic, high-resolution population data and the modeling infrastructure to run scenario planning at scale. Together, these capabilities let decision-makers stress-test strategies in a controlled environment before deploying them in the real world across healthcare, consumer industries, insurance, and government. We are approaching our Series B and actively building the team that will define what comes next.

Responsibilities

Operational Infrastructure

• Organizational Systems: Support the COO in designing and maintaining internal systems that enable the organization to operate effectively. This includes shaping the structure of internal resources, playbooks, and working frameworks so that teams have clear guidance, consistent information, and easy access to the tools they need to execute.

• Institutional Knowledge: Maintain key internal resources so critical information, decisions, and processes remain visible, searchable, and easy for teams to navigate as the company grows.

• Execution & Change Management: Partner with the COO to lead internal initiatives, introducing improved ways of working, and supporting teams as new systems or operational practices are implemented. Review and refine internal resources, documentation, and operational frameworks to ensure they are consistent, practical, and aligned with the organization’s evolving needs.