Director, Office of the CEO

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We are seeking exceptional entrepreneurial builders to join BillionToOne's newly launched Founder in Residence Program as a Director, Office of the CEO. In this 12 to 18 month program, you will work directly with the CEO and Chief of Staff on the company's highest-priority strategic and operational projects, and graduate into a permanent senior operating role at the Director or Senior Director level.

This is one of the highest-leverage roles at BillionToOne. You will be deployed onto a portfolio of high-impact projects each quarter — from new product launches, to commercial strategy, to operational turnarounds, to incubating new business lines and capabilities. Your portfolio of 1-2 projects will be revisited each quarter so you are always working on what matters most to the company.

The ideal candidate is a first-principles thinker, a builder, AI-native, and exceptionally sharp. You have founded a company, operated at the most senior level of a top scaleup, or built a track record of high-impact strategic work, and you are looking for your next high-leverage seat — one that gives you scale, mission, and direct CEO exposure without starting from scratch.

This role is a hybrid (onsite 3 days/week) position and reports directly to the VP of Business Operations and Chief of Staff, with active co-sponsorship from the CEO.

Responsibilities:

• Own CEO-Priority Projects: Lead one or more of BillionToOne's highest-priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO. Project types span new product launch support, commercial and go-to-market strategy, business development, operational excellence, competitive response, and the incubation of new business lines.
• Find Broken Things and Fix Them: Identify under-performing processes, workflows, or functions. Diagnose root cause, design the fix, and drive execution end-to-end with cross-functional teams.
• Cross-Functional Leadership: Lead and influence cross-functional teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR. Build deep working knowledge of how each function operates through the projects you lead.
• Operate with AI: Drive results in ambiguous, fast-moving environments. Use first-principles thinking and AI-native fluency to move faster than the company would otherwise be able to.
• CEO and Executive Partnership: Participate in CEO meetings, present to the executive team on an ongoing basis, and serve as a trusted thought partner to the CEO and Chief of Staff on company-shaping decisions.

Qualifications:

• 6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
• One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt. 
• First-principles thinker with exceptional analytical horsepower
• Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
• AI-native fluency in using AI tools to move faster and amplify individual leverage
• Strong written and verbal communication, including with executives and the Board
• Genuine interest in molecular diagnostics and the BillionToOne mission
• On-site position (relocation to SF Bay Area required)

Nice-To-Haves:

• Prior exposure to healthcare, life sciences, molecular diagnostics, or other regulated industries
• Track record of building 0 to 1 — new products, new functions, new business lines, or new operating mechanisms
• Existing network in the founder community, YC ecosystem, or top scaleup operating community

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of (1) competitive base pay, (2) the opportunity for professional growth, and (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave etc.).

For this position, we offer a total compensation package of $460,105 per year, including a base pay range of $203,651- $225,088 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com