Product Manager

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

We are seeking a Principal Product Manager, Chemistry to deliver products and capabilities that help Chemistry teams make faster, higher-confidence design and progression decisions in oncology-focused drug discovery.

This role will define and deliver the product strategy for Chemistry workflows, data products, and AI-enabled decision support using the right mix of internal product development, SaaS platforms, vendor partnerships, integrations, and RevCore capabilities. You will partner with medicinal chemists, synthetic chemists, computational chemists, analytical chemists, DMPK and Biology partners, Data Science, ML Engineering, Data Engineering, IT, and platform teams to turn complex Chemistry workflows into intuitive, scalable solutions that accelerate the Design-Make-Test-Learn cycle.

Own Chemistry product strategy

• Define the vision and roadmap for Chemistry products and capabilities across medicinal chemistry, synthetic chemistry, analytical chemistry, compound management, and the Design-Make-Test-Learn cycle.

• Build a Now, Next, Later roadmap from foundational compound data capabilities to self-service analytics, model-supported design, and AI-enabled decision support.

• Set success metrics tied to trusted compound data access, reduced manual data preparation, faster design cycles, compound progression decisions, and scientific adoption.

Shape product solutions around Chemistry workflows and decisions

• Understand workflows for medicinal chemists, synthetic chemists, computational chemists, analytical chemists, compound management teams, and cross-functional program teams.

• Design solutions around key decision moments such as compound design, analog selection, route selection, synthesis planning, SAR interpretation, multi-parameter optimization, compound triage, and program prioritization.

• Translate Chemistry workflows into clear product requirements, evaluation criteria, user stories, and prioritized capabilities.