Associate Scientist

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

We are seeking an experienced and highly organized In Vivo Study Coordinator to own the end-to-end planning, coordination, and execution of our preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence — you will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, collection, and delivery.

The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are as comfortable building a detailed study timeline as you are troubleshooting a dosing day in real time — and you know when to push back on unrealistic timelines and when to find creative solutions.

Key Responsibilities

• Work closely with pharmacology team members to oversee and execute assays assessing the pharmacological activity, biodistribution, and efficacy of test articles in research and preclinical studies, supporting development of therapies across the pipeline.
• Manage tissue analysis and oversee the transfer and storage of samples from rodent and large animal studies performed at external contract vivarium facilities.
• Perform test article dosing via various administration routes, including systemic administration (I.V., I.P.).
• Perform rodent perfusion and tissue collection.
• Independently analyze and interpret data, with careful documentation of experiments and presentation of results within the company.
• Perform various molecular and biochemical assays on tissue samples from preclinical studies across a range of drug development programs, including quantitative and qualitative target analysis.

Required Qualifications

• Bachelor's or Master's degree in Biology, Pharmacology, Biomedical Science, or related field
• 5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment